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KMID : 0381919980280010073
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Korean Journal of Microscopy
1998 Volume.28 No. 1 p.73 ~ p.82
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Fine Structure of Pericanalicular Cytoplasm of Taurocholic Acid-treated Rat Liver as Revealed by Deep Etching with Rapid Freezing
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Shin Young-Chul
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Abstract
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To elucidate how microfilaments and vesicles participate in bile formation, the pericanalicular cytoplasms were observed in the liver of rats treated with taurocholic acid by deep etching with rapid freezing, and copmpared them with the findings on convensional thin sections. The microfilaments were identified around the bile canaliculi in the forms of core filaments of microvilli, filaments of pericanalicular web running in parallel to the border of bile canaliculi, and filaments on the junctional complex. In taurocholic acid-treated rats, microfilaments could be visualized around the bile canaliculi and along their borders. The microfilaments appeared to be installed to link to both the canalicular membrane and vesicles. Such specialized microfilaments are considered to participate in the translocation of vesicles in the pericanalicular cytoplasm. From the evidence, it is assumed that the microfilament induces the vesicles to transport and fuse to bile canalicull into which bile acids is secreted by exocytosis.
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KEYWORD
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Pericanalicular cytoplasm, Golgi apparatus, Vesicle, Microfilament, Liver, Rat, Deep etching, Rapid freezing
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